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Single-cell sequencing of peripheral blood and tumor-infiltrating immune cells in renal clear cell carcinoma [5' RNA expression sequencing]

We generated a comprehensive immune profile using single-cell RNA-seq data from 25,000 immune cells from three renal cell carcinoma along with matched peripheral blood. In addition, we performed VDJ sequencing on the isolated single T cells. In order to investigate heterogeneity and dynamics of cancer-associated immune cells, we performed single-cell sequencing on peripheral and tumor-infiltrating immune cells in three renal clear cell carcinoma patients. We chose renal clear cell carcinoma tumors based on the responsive of these tumors to immune checkpoint blockade in the context of low mutational loads, which implies a strong influence from the tumor microenvironment. Using the 10x Genomic 5 expression platform a total of 25,672 immune cells were isolated and passed filtering for quality control, with 13,433 cells from peripheral blood and 12,239 tumor-infiltrating cells. In addition, we used the Chromium Single Cell V(D)J kit to enrich for T cell receptor sequences for nearly 10,000 T cells in with accompanying expression information, allowing for the investigation of clonality and transcriptional phenotypic diversity.

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Preview Accession Estimated No. of Cells Mean Reads per Cell Median Genes per Cell No. of Reads % Valid Barcodes % sequencing Saturation % Q30 Bases in Barcode % Q30 Bases in UMI % Reads Mapped to Genome % Reads Mapped Confidently to Genome % Reads Mapped Confidently to Intergenic Regions % Reads Mapped Confidently to Intronic Regions % Reads Mapped Confidently to Exonic Regions % Reads Mapped Confidently to Transcriptome % Reads Mapped Antisense to Gene % Fraction Reads in Cells Total Genes Detected Median UMI Counts Per Cell

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CAGE Transcription Start Site (CTSS) File Download

The CTSS positions were taken from dataset BAM files, downloadable here.



Top 10 Marker Genes per Cluster



Seurat Cluster Gene Symbol P Value Average Log Pct 1 Pct 2 Adjusted P Value
0 CD8A 1.19E-93 2.8587132 None None 2.57E-89
0 RPL28 5.50E-54 0.41761374 None None 2.37E-50
0 CD3D 1.77E-40 1.3597426 None None 5.43E-37
0 ITM2C 1.13E-57 2.5000272 None None 6.09E-54
0 GZMA 6.62E-36 1.3142344 None None 1.78E-32
0 CD8B 2.89E-80 2.8199399 None None 2.07E-76
0 CXCR4 3.78E-33 1.0549213 None None 8.15E-30
0 GZMK 4.82E-89 3.1574037 None None 5.19E-85
0 APOBEC3G 7.29E-31 1.1466389 None None 1.43E-27
0 TMSB4X 5.57E-44 0.43165794 None None 2.00E-40
1 IL7R 1.67E-67 2.6165576 None None 1.20E-63
1 SLC2A3 1.68E-41 1.378429 None None 2.41E-38
1 TPT1 2.08E-66 0.6149006 None None 1.12E-62
1 VIM 1.16E-80 1.495651 None None 1.25E-76
1 CD52 5.37E-52 1.3595276 None None 1.29E-48
1 CDKN1A 1.49E-43 1.8643354 None None 2.67E-40
1 ICOS 4.19E-41 1.9290165 None None 5.64E-38
1 GPR183 1.45E-49 2.3875952 None None 3.13E-46
1 RPLP1 7.94E-42 0.4735864 None None 1.22E-38
1 RPL28 6.62E-63 0.49178523 None None 2.85E-59
2 CMC1 2.37E-77 2.6757371 None None 1.70E-73
2 CD247 8.33E-40 1.4378783 None None 1.79E-36
2 TYROBP 2.94E-79 3.0832088 None None 3.17E-75
2 KLRD1 8.46E-92 2.9679558 None None 1.82E-87
2 KLRB1 2.62E-71 2.822737 None None 1.41E-67
2 KLRF1 2.77E-51 3.235398 None None 7.46E-48
2 NKG7 5.02E-37 2.114852 None None 8.32E-34
2 KLRC2 2.75E-58 3.458914 None None 8.46E-55
2 KLRK1 2.40E-42 1.8411286 None None 5.75E-39
2 TRDC 3.50E-37 2.7720666 None None 6.29E-34
3 PRF1 3.48E-152 3.6729715 None None 7.50E-148
3 FCGR3A 7.14E-140 4.2721705 None None 3.08E-136
3 NKG7 5.51E-143 3.3138227 None None 2.97E-139
3 CD247 3.59E-116 2.530787 None None 9.66E-113
3 FGFBP2 1.21E-119 4.099715 None None 3.71E-116
3 KLRD1 1.86E-107 3.2563198 None None 4.44E-104
3 GNLY 4.20E-148 4.916917 None None 3.02E-144
3 SPON2 1.73E-132 4.6161656 None None 6.22E-129
3 MYOM2 9.35E-98 4.990933 None None 2.01E-94
3 GZMB 3.19E-149 4.118154 None None 3.44E-145
4 HLA-C 7.91E-37 0.60495585 None None 1.89E-33
4 GZMH 5.61E-84 2.774457 None None 1.21E-79
4 GZMB 5.66E-56 2.4718456 None None 2.44E-52
4 CD8A 6.03E-81 3.0618806 None None 6.49E-77
4 FGFBP2 5.30E-50 2.6435487 None None 1.90E-46
4 NKG7 1.49E-71 2.60497 None None 1.07E-67
4 KLRD1 9.71E-40 2.0356977 None None 2.61E-36
4 CD8B 2.77E-61 2.7477021 None None 1.49E-57
4 CD3G 4.16E-31 1.5327085 None None 8.96E-28
4 KLRC4 7.46E-49 2.6813235 None None 2.30E-45
5 B2M 2.47E-36 0.4523941 None None 1.33E-32
5 LYAR 2.10E-23 1.5687153 None None 4.11E-20
5 IL7R 8.24E-30 2.084955 None None 2.54E-26
5 HLA-C 5.08E-36 0.66153383 None None 2.19E-32
5 S100A10 3.72E-27 1.0920494 None None 1.00E-23
5 ANXA1 3.91E-26 1.5997603 None None 9.36E-23
5 FGFBP2 3.42E-47 2.735704 None None 3.68E-43
5 CD52 7.09E-32 1.2980722 None None 2.55E-28
5 NKG7 2.54E-41 2.2611525 None None 1.82E-37
5 GZMH 4.33E-80 2.9385083 None None 9.33E-76
6 CD27 6.97E-109 4.1440916 None None 7.51E-105
6 TOX 2.08E-79 3.208373 None None 7.47E-76
6 HLA-DQA1 5.44E-67 2.7045834 None None 1.07E-63
6 CD74 4.28E-68 2.1227221 None None 9.23E-65
6 LYST 9.03E-90 3.0849836 None None 6.49E-86
6 GZMK 1.82E-132 5.064838 None None 3.93E-128
6 CST7 3.81E-76 2.0718205 None None 1.17E-72
6 CMC1 1.25E-75 2.971285 None None 3.36E-72
6 CD8B 2.59E-71 3.3858225 None None 6.20E-68
6 CD8A 1.63E-86 3.5769196 None None 8.79E-83
7 CD27 3.09E-65 3.0157511 None None 5.12E-62
7 S100A4 9.33E-70 1.91282 None None 2.23E-66
7 TNFRSF18 6.19E-68 4.102734 None None 1.33E-64
7 CORO1B 7.59E-77 2.954491 None None 3.27E-73
7 LTB 1.23E-70 2.9290364 None None 3.32E-67
7 IL32 1.26E-111 2.299458 None None 2.72E-107
7 BATF 9.33E-83 3.2072046 None None 5.03E-79
7 TBC1D4 7.71E-71 4.5341253 None None 2.37E-67
7 FOXP3 6.38E-108 10.805433 None None 6.88E-104
7 CARD16 1.97E-65 2.5818732 None None 3.54E-62
8 KIR2DL4 3.90E-92 6.49047 None None 1.40E-88
8 HOPX 3.88E-96 3.43063 None None 1.67E-92
8 TMIGD2 1.03E-81 4.871055 None None 2.21E-78
8 XCL1 6.48E-92 4.3454037 None None 2.00E-88
8 CD7 7.77E-110 3.5082643 None None 1.67E-105
8 KLRB1 1.71E-96 4.0399847 None None 9.23E-93
8 KRT81 1.47E-103 6.4350424 None None 1.59E-99
8 TRDC 8.85E-88 4.946257 None None 2.38E-84
8 KRT86 3.16E-97 5.741669 None None 2.27E-93
8 ZNF683 2.60E-82 4.0297575 None None 6.22E-79
9 RORA 2.15E-29 1.7347444 None None 6.62E-26
9 ZNF683 1.04E-23 2.1412146 None None 2.03E-20
9 B2M 3.40E-25 0.42306694 None None 7.32E-22
9 GZMH 3.12E-58 2.8316529 None None 3.36E-54
9 GNLY 1.82E-34 2.687875 None None 7.85E-31
9 ANXA1 4.53E-26 1.7466844 None None 1.08E-22
9 TRBV2 2.30E-102 7.032297 None None 4.95E-98
9 HLA-C 3.40E-26 0.63844687 None None 9.15E-23
9 CD52 3.39E-35 1.468536 None None 1.83E-31
9 TRAV2 2.82E-57 5.755636 None None 2.03E-53
10 RPL10 1.97E-90 1.0274795 None None 7.08E-87
10 RPL13 1.19E-89 1.1609336 None None 3.65E-86
10 RPL11 4.41E-89 1.0773872 None None 1.06E-85
10 RPL34 3.85E-89 1.0502244 None None 1.04E-85
10 RPS6 1.76E-88 1.2796806 None None 3.78E-85
10 RPS8 1.82E-96 1.4294918 None None 3.93E-92
10 RPS12 4.37E-95 1.2488374 None None 4.70E-91
10 RPS3A 7.89E-95 1.2881902 None None 5.66E-91
10 RPL32 1.18E-94 1.2850106 None None 6.36E-91
10 EEF1A1 5.26E-93 0.99906784 None None 2.27E-89
11 CD74 2.86E-77 4.1154714 None None 3.08E-73
11 HLA-DPB1 7.22E-74 4.543598 None None 5.19E-70
11 TYROBP 6.82E-57 4.102228 None None 1.47E-53
11 FTL 5.49E-73 3.1924398 None None 2.96E-69
11 CST3 1.03E-66 6.956228 None None 3.70E-63
11 HLA-DRB1 3.73E-60 4.102569 None None 1.15E-56
11 HLA-DPA1 9.90E-70 4.7714224 None None 4.27E-66
11 NPC2 8.66E-59 4.152652 None None 2.33E-55
11 HLA-DRA 4.39E-78 5.8234687 None None 9.45E-74
11 LYZ 1.21E-58 6.117744 None None 2.89E-55
12 RPS23 1.60E-60 1.0724887 None None 3.46E-57
12 CD74 1.27E-72 3.6613355 None None 1.37E-68
12 MS4A1 7.58E-60 7.9732013 None None 1.26E-56
12 CD37 8.63E-70 2.5045464 None None 4.65E-66
12 RPL18A 3.26E-60 1.20425 None None 6.38E-57
12 RPS5 5.76E-60 1.383677 None None 1.04E-56
12 HLA-DRA 5.24E-71 4.8271017 None None 3.76E-67
12 CD79A 1.15E-72 9.40259 None None 1.37E-68
12 RPS8 2.02E-66 1.3193978 None None 8.70E-63
12 CD83 4.73E-64 4.1396923 None None 1.46E-60
13 FTL 3.26E-69 3.12478 None None 7.28E-66
13 LST1 2.99E-72 6.460263 None None 1.29E-68
13 S100A6 7.50E-71 2.777976 None None 2.02E-67
13 S100A8 3.38E-69 10.353324 None None 7.28E-66
13 IFI30 3.07E-71 6.8211684 None None 9.46E-68
13 FCN1 9.89E-76 10.16219 None None 2.13E-71
13 S100A9 5.97E-74 10.052001 None None 4.28E-70
13 AIF1 1.08E-71 6.379124 None None 3.89E-68
13 CTSS 7.69E-73 4.6479344 None None 4.14E-69
13 LYZ 8.11E-75 8.397457 None None 8.74E-71
14 TRBV11-1 1.20E-36 8.366204 None None 2.59E-32
14 TRGV2 4.38E-19 4.1101823 None None 3.15E-15
14 IKZF2 1.45E-10 3.0117996 None None 3.48E-07
14 KLRD1 2.31E-13 2.28118 None None 9.96E-10
14 CD8A 7.23E-16 2.6398816 None None 3.90E-12
14 KLRC2 1.13E-11 2.5274816 None None 3.04E-08
14 TRAV38-1 3.14E-28 8.716557 None None 3.38E-24
14 AOAH 3.57E-10 1.8251185 None None 7.69E-07
14 CST7 1.11E-12 1.6187695 None None 4.00E-09
14 TRGV8 1.42E-12 4.973506 None None 4.38E-09
15 KLRC2 1.23E-10 3.553072 None None 2.65E-06
15 LINC02446 3.46E-10 4.0447636 None None 2.73E-06
15 KIR2DL3 9.74E-06 3.3014493 None None 0.01166169
15 CD8A 3.93E-06 1.8819908 None None 0.006354298
15 PARP8 2.16E-08 1.8281056 None None 9.31E-05
15 TRBV4-2 3.79E-10 6.488491 None None 2.73E-06
15 TRAV9-2 9.62E-08 4.808992 None None 0.000296193
15 ZNF683 6.60E-08 2.6459794 None None 0.000237037
15 TRAV14DV4 8.32E-10 5.4414167 None None 4.48E-06
15 GNLY 1.94E-05 2.2904282 None None 0.019021102
16 TUBA1B 2.87E-08 2.5586846 None None 6.42E-05
16 PTMA 2.98E-08 0.9540778 None None 6.42E-05
16 STMN1 2.10E-16 6.368981 None None 4.53E-12
16 MCM7 1.82E-08 4.4914365 None None 4.90E-05
16 DUT 1.29E-10 3.4457784 None None 5.54E-07
16 HMGN2 1.84E-11 2.5458071 None None 9.89E-08
16 HMGB2 1.02E-09 2.7296002 None None 3.67E-06
16 HMGB1 1.12E-11 1.9796633 None None 8.05E-08
16 TUBB 7.02E-14 3.4399862 None None 7.56E-10
16 PCLAF 1.31E-09 7.678967 None None 4.04E-06
17 HLA-DQA1 9.96E-07 3.4347825 None None 0.004293218
17 HLA-DRB1 6.16E-05 2.4919496 None None 0.046375216
17 CD74 7.42E-10 3.4090455 None None 1.60E-05
17 HLA-DPB1 7.45E-06 2.7552185 None None 0.013375036
17 RAB11FIP1 2.99E-05 2.8212225 None None 0.034151068
17 SEC61B 2.95E-06 2.1932468 None None 0.009080804
17 HLA-DRA 5.73E-07 3.8493285 None None 0.003085111
17 CST3 6.24E-05 4.205586 None None 0.046375216
17 HLA-DQB1 1.90E-08 4.1797943 None None 0.000204608
17 GPR183 3.61E-06 3.3814793 None None 0.009578947
18 IGHV3-48 2.30E-13 17.818605 None None 5.83E-10
18 IGKV4-1 2.75E-13 10.159618 None None 5.83E-10
18 IGLV6-57 2.35E-13 14.010626 None None 5.83E-10
18 SSR4 3.13E-13 3.3498292 None None 5.83E-10
18 JCHAIN 2.30E-13 14.0188875 None None 5.83E-10
18 IGLV2-23 2.30E-13 14.982982 None None 5.83E-10
18 IGLC3 2.63E-13 9.567198 None None 5.83E-10
18 IGLC2 2.37E-13 11.671875 None None 5.83E-10
18 IGLV1-51 2.30E-13 18.472261 None None 5.83E-10
18 IGHA1 2.36E-13 10.911486 None None 5.83E-10
19 SLC18A2 1.01E-06 11.96207 None None 0.003199408
19 TPSB2 9.92E-07 36.004055 None None 0.003199408
19 NFKBIZ 3.02E-06 3.9657052 None None 0.006401666
19 LGALS3 3.27E-06 4.406324 None None 0.006401666
19 HPGDS 9.92E-07 12.755974 None None 0.003199408
19 IFITM3 2.08E-06 5.7507906 None None 0.005290566
19 TPSAB1 9.92E-07 36.15246 None None 0.003199408
19 LTC4S 1.04E-06 7.800258 None None 0.003199408
19 TPSD1 9.92E-07 33.3278 None None 0.003199408
19 GATA2 9.97E-07 12.309232 None None 0.003199408
20 CD24 0.000547326 8.976716 None None 0.841126564
20 MIF 0.000557458 3.9596696 None None 0.841126564
20 ANXA4 0.00055653 6.20768 None None 0.841126564
20 CRYAB 0.000552831 11.08684 None None 0.841126564
20 NNMT 0.000537366 10.881002 None None 0.841126564
20 RARRES2 0.000537366 13.175091 None None 0.841126564
20 ADIRF 0.000536468 11.7633705 None None 0.841126564
20 NDUFA4L2 0.000536468 11.499596 None None 0.841126564
20 CCND1 0.000560252 8.150952 None None 0.841126564
20 SPP1 0.000561186 9.421297 None None 0.841126564
0 TRDV1 5.03E-149 5.2049212 None None 1.04E-144
0 CCL5 8.38E-84 1.7475934 None None 3.45E-80
0 TRBC1 5.45E-71 2.3444366 None None 1.87E-67
0 FXYD2 1.98E-92 3.371689 None None 1.36E-88
0 LAG3 3.33E-70 2.2509322 None None 9.79E-67
0 CST7 6.25E-68 1.3879806 None None 1.61E-64
0 TRGV8 1.79E-115 5.200185 None None 1.84E-111
0 PMCH 5.30E-62 4.041238 None None 1.21E-58
0 RTKN2 2.69E-90 3.894126 None None 1.39E-86
0 GZMK 2.22E-60 2.136469 None None 4.58E-57
1 RPS28 2.05E-93 0.70708203 None None 3.25E-90
1 TPT1 1.14E-93 0.8184955 None None 1.96E-90
1 RPS29 3.73E-97 0.9533093 None None 8.54E-94
1 IL7R 2.41E-125 5.294469 None None 2.48E-121
1 RPS18 4.35E-113 1.08265 None None 2.24E-109
1 RPS12 8.99E-100 0.8188261 None None 2.32E-96
1 RPS14 1.64E-94 0.7421732 None None 3.08E-91
1 RPL39 6.12E-111 0.83440495 None None 2.52E-107
1 RPL13 2.47E-96 0.7918664 None None 5.10E-93
1 RPL28 1.69E-101 0.7055643 None None 5.80E-98
2 KLRD1 3.17E-170 5.8884687 None None 6.53E-166
2 KLRB1 2.93E-150 5.161805 None None 8.64E-147
2 MYOM2 1.16E-121 7.9353933 None None 1.85E-118
2 FCGR3A 3.94E-142 5.0431314 None None 7.39E-139
2 SPON2 1.19E-150 5.44539 None None 4.08E-147
2 GZMB 9.57E-164 4.9396663 None None 9.87E-160
2 FGFBP2 2.69E-145 6.9124427 None None 5.55E-142
2 KLRF1 1.17E-151 6.9599466 None None 4.85E-148
2 GNLY 8.23E-146 5.785733 None None 2.12E-142
2 TYROBP 7.11E-154 5.512248 None None 3.67E-150
3 TRBC2 1.25E-84 2.0088816 None None 5.14E-81
3 HLA-DRB1 9.41E-34 1.5662109 None None 1.76E-30
3 CD8A 4.10E-106 3.5746958 None None 2.12E-102
3 CD74 1.34E-48 1.6144336 None None 3.95E-45
3 TRAV12-2 1.41E-164 7.459789 None None 2.90E-160
3 CST7 9.05E-36 1.2156875 None None 1.87E-32
3 TRBV20-1 3.46E-160 7.4017277 None None 3.56E-156
3 CD3D 1.41E-39 1.2649648 None None 3.22E-36
3 CD8B 1.83E-114 3.570796 None None 1.26E-110
3 TRAV22 3.17E-47 5.609035 None None 8.18E-44
4 GZMK 2.76E-28 1.8614542 None None 1.14E-24
4 HLA-DQA1 1.87E-27 1.2658111 None None 6.43E-24
4 ITM2A 2.67E-27 1.4623935 None None 7.88E-24
4 HLA-DRB1 1.15E-28 1.4541706 None None 5.92E-25
4 CD74 4.43E-27 1.2593561 None None 1.14E-23
4 IL32 6.19E-27 1.1813821 None None 1.42E-23
4 HLA-DPA1 2.22E-22 1.0439669 None None 4.59E-19
4 GZMA 1.62E-43 1.3160347 None None 1.11E-39
4 CD8A 7.56E-71 3.0120423 None None 1.56E-66
4 CD8B 3.06E-48 2.3247714 None None 3.16E-44
5 TRBV27 9.41E-46 6.9738126 None None 6.47E-42
5 HLA-DRB1 7.10E-23 1.612445 None None 1.83E-19
5 MIR155HG 3.84E-28 2.118051 None None 1.58E-24
5 HLA-DQA1 3.15E-27 1.570564 None None 1.08E-23
5 CD8B 1.17E-48 2.8498526 None None 1.20E-44
5 ITM2A 3.79E-22 1.6475544 None None 8.69E-19
5 CD8A 1.95E-55 3.2573721 None None 4.02E-51
5 RGS1 1.08E-31 1.6014444 None None 5.57E-28
5 CD74 6.97E-24 1.4203441 None None 2.05E-20
5 TOX 1.34E-20 1.3854719 None None 2.76E-17
6 TRDV1 1.69E-69 4.4375863 None None 1.16E-65
6 CST7 5.01E-49 1.5411795 None None 1.29E-45
6 CMC1 5.30E-67 2.926847 None None 2.73E-63
6 CADM1 2.04E-64 3.2880013 None None 8.42E-61
6 TRGV2 5.04E-99 5.7740235 None None 5.20E-95
6 ADTRP 4.92E-53 3.2336936 None None 1.69E-49
6 SNAP47 1.01E-43 2.2887201 None None 2.07E-40
6 RTKN2 2.70E-44 3.1905751 None None 6.19E-41
6 TRBV24-1 1.31E-103 9.222713 None None 2.70E-99
6 PRF1 6.44E-51 2.1697352 None None 1.90E-47
7 TIGIT 6.89E-35 2.7013485 None None 1.09E-31
7 SLAMF1 1.13E-29 5.1521993 None None 1.17E-26
7 SAMSN1 1.23E-34 2.3005114 None None 1.70E-31
7 S100A4 1.17E-34 1.5251157 None None 1.70E-31
7 AL136456.1 3.53E-42 6.38125 None None 8.09E-39
7 BATF 6.23E-34 2.4792938 None None 8.03E-31
7 CARD16 5.17E-37 2.2752135 None None 9.69E-34
7 IL32 7.14E-36 1.7259804 None None 1.23E-32
7 TBC1D4 2.76E-37 3.9934206 None None 5.69E-34
7 FOXP3 1.72E-45 10.53366 None None 5.06E-42
8 RPS12 4.39E-23 0.78257895 None None 2.27E-19
8 RPL34 1.51E-20 0.69590795 None None 3.11E-17
8 ANXA1 7.67E-21 3.2829123 None None 2.03E-17
8 RPS18 1.51E-20 0.90979 None None 3.11E-17
8 GZMH 3.08E-28 3.447106 None None 6.26E-24
8 CD52 5.95E-21 2.213187 None None 2.03E-17
8 RPL3 2.86E-24 1.1093147 None None 1.96E-20
8 RPL14 7.34E-23 0.9387594 None None 3.03E-19
8 GNLY 6.07E-28 4.903165 None None 6.26E-24
8 RPL39 7.86E-21 0.74630654 None None 2.03E-17
9 CD52 8.77E-15 2.1164992 None None 2.26E-11
9 PARP8 2.17E-13 1.8182665 None None 3.72E-10
9 LINC02446 2.00E-27 8.554037 None None 4.12E-23
9 RPS18 3.23E-14 0.8959564 None None 7.39E-11
9 XCL1 3.76E-21 4.9915085 None None 1.55E-17
9 ZNF683 5.44E-27 7.324744 None None 5.61E-23
9 KLRD1 2.28E-15 3.4238079 None None 6.72E-12
9 XCL2 1.41E-22 4.391644 None None 7.26E-19
9 LINC01871 1.31E-23 4.0254602 None None 8.98E-20
9 RPL30 2.72E-13 0.62497574 None None 4.32E-10
10 NPC2 2.38E-24 4.7312512 None None 4.90E-21
10 PSAP 1.69E-23 3.2482016 None None 2.68E-20
10 IFI30 1.78E-28 6.7048016 None None 1.22E-24
10 TYROBP 3.43E-26 5.4186068 None None 1.01E-22
10 FTH1 1.05E-28 3.0804482 None None 1.08E-24
10 SAT1 3.50E-24 3.2720234 None None 6.56E-21
10 CST3 2.80E-29 8.307303 None None 5.77E-25
10 FTL 6.51E-24 2.613273 None None 1.12E-20
10 LYZ 9.94E-28 8.020203 None None 4.10E-24
10 SERPINA1 5.69E-28 8.738053 None None 2.93E-24
11 HLA-DRB1 3.32E-13 2.293948 None None 6.85E-09
11 ACTB 8.76E-10 0.8309032 None None 1.50E-06
11 CD8B 2.47E-09 2.373406 None None 3.64E-06
11 HMGN2 8.76E-11 1.8013859 None None 3.09E-07
11 CD74 4.42E-11 1.790008 None None 2.56E-07
11 TUBB 7.66E-10 2.0380316 None None 1.44E-06
11 HLA-DPA1 3.37E-10 1.6734071 None None 8.69E-07
11 HLA-DRA 4.96E-11 2.2222006 None None 2.56E-07
11 NUCKS1 3.14E-09 1.9195594 None None 4.32E-06
11 STMN1 9.00E-11 4.124918 None None 3.09E-07
12 KLRB1 2.25E-14 4.2237406 None None 1.16E-10
12 KLRK1 2.31E-09 2.1302605 None None 4.32E-06
12 KLRD1 1.78E-14 4.211657 None None 1.16E-10
12 MAPK1 1.98E-09 3.057204 None None 4.08E-06
12 AREG 1.58E-15 4.653966 None None 1.63E-11
12 TYROBP 4.87E-16 4.5654655 None None 1.00E-11
12 CD7 2.61E-09 2.2758543 None None 4.49E-06
12 XCL2 4.13E-10 4.208623 None None 9.47E-07
12 KRT81 1.34E-11 8.093541 None None 3.96E-08
12 KRT86 6.06E-12 5.7058063 None None 2.08E-08
13 THEMIS 2.45E-05 2.0682106 None None 0.063238225
13 RASSF4 7.86E-06 3.2018213 None None 0.032421805
13 ZNF331 6.90E-05 1.6480713 None None 0.142331978
13 CD8A 8.86E-07 2.8535736 None None 0.004566293
13 TRBV9 3.04E-13 9.503804 None None 3.13E-09
13 TRAV12-1 1.42E-14 9.530298 None None 2.92E-10
13 INPP4B 5.29E-05 2.1565351 None None 0.121236155
13 FXYD2 1.89E-05 2.5244644 None None 0.055775774
13 TRBC1 1.21E-05 2.0431604 None None 0.04153189
13 TRAV13-2 5.06E-12 8.238698 None None 3.48E-08
14 CD83 9.28E-06 4.7951975 None None 0.037163448
14 BANK1 2.00E-05 9.310735 None None 0.038847197
14 RPL39 1.76E-05 1.1604788 None None 0.038847197
14 CD74 1.08E-05 2.966309 None None 0.037163448
14 HLA-DRA 6.56E-06 4.187017 None None 0.033805007
14 EEF1B2 4.99E-06 1.9394693 None None 0.033805007
14 RPS23 2.27E-06 1.3514445 None None 0.023417897
14 RPS8 1.42E-06 1.6516064 None None 0.023417897
14 RPL5 2.07E-05 1.2544245 None None 0.038847197
14 EEF1A1 2.68E-05 0.8981809 None None 0.03971606
0 GZMK 4.47E-88 3.3531203 None None 8.75E-84
0 TOX 8.30E-52 2.46705 None None 1.81E-48
0 TNFRSF9 1.28E-52 3.9047792 None None 3.13E-49
0 ITM2A 9.28E-53 2.4601214 None None 2.60E-49
0 HLA-DRB1 7.32E-59 2.3234966 None None 2.39E-55
0 DUSP4 1.60E-59 2.4575663 None None 6.27E-56
0 LYST 1.77E-67 2.8303115 None None 8.67E-64
0 CD27 1.65E-70 3.072759 None None 1.07E-66
0 CD74 4.59E-84 2.3717654 None None 4.49E-80
0 HLA-DPA1 1.75E-51 2.1326742 None None 3.42E-48
1 GZMM 2.47E-13 1.3943533 None None 4.83E-10
1 RPS15A 1.19E-22 0.71340626 None None 1.17E-18
1 GZMA 6.06E-17 1.3815374 None None 2.37E-13
1 RPS29 1.45E-26 0.86021554 None None 2.83E-22
1 RPL13 5.33E-16 0.61988056 None None 1.74E-12
1 CD8A 1.41E-15 1.612694 None None 3.45E-12
1 RPS27 4.67E-19 0.673162 None None 2.29E-15
1 RPL23A 3.21E-14 0.70707804 None None 6.99E-11
1 GZMK 2.82E-19 2.0856142 None None 1.84E-15
1 CD8B 7.89E-16 1.6511674 None None 2.21E-12
2 KLRF1 2.95E-49 6.2614794 None None 9.64E-46
2 NKG7 6.83E-58 2.749358 None None 3.34E-54
2 PRF1 5.34E-43 2.7532237 None None 1.05E-39
2 GNLY 2.09E-51 5.346766 None None 8.19E-48
2 GZMB 6.94E-49 4.825422 None None 1.94E-45
2 KLRB1 3.69E-65 4.6943645 None None 3.61E-61
2 KLRD1 7.21E-65 4.658858 None None 4.71E-61
2 CD7 1.39E-38 2.578242 None None 2.48E-35
2 TYROBP 4.09E-71 4.788502 None None 8.02E-67
2 IFITM1 4.49E-43 2.0724273 None None 9.77E-40
3 RPS18 4.31E-31 0.9185822 None None 8.86E-28
3 TPT1 4.83E-48 1.0312977 None None 4.73E-44
3 RPS21 5.77E-30 0.8176789 None None 1.03E-26
3 RPL34 4.53E-31 0.78957444 None None 8.86E-28
3 EEF1A1 1.37E-31 0.7429849 None None 3.35E-28
3 CD52 9.12E-33 1.6407712 None None 2.55E-29
3 RPS12 1.02E-34 0.83967346 None None 3.33E-31
3 RPL11 7.64E-30 0.7732554 None None 1.25E-26
3 IL7R 5.32E-64 4.3823886 None None 1.04E-59
3 RPL39 7.99E-35 0.8586577 None None 3.13E-31
4 CCL5 1.50E-10 1.5324768 None None 1.83E-07
4 RPS15A 5.71E-16 0.70234215 None None 1.40E-12
4 RPL30 9.56E-11 0.6117119 None None 1.25E-07
4 GZMA 2.26E-11 1.3514099 None None 3.16E-08
4 RPL13 1.19E-11 0.62245244 None None 1.80E-08
4 GZMK 1.83E-10 1.7762877 None None 2.10E-07
4 RPS29 2.14E-15 0.71739125 None None 4.65E-12
4 RPS27 4.82E-10 0.6376603 None None 5.13E-07
4 CD8A 1.16E-14 1.8838103 None None 2.06E-11
4 ITM2C 2.55E-13 1.8598926 None None 4.16E-10
5 RPS27 1.64E-09 0.54968554 None None 3.08E-06
5 GZMH 3.59E-17 2.4067864 None None 3.51E-13
5 NKG7 1.93E-10 1.6874326 None None 4.20E-07
5 GNLY 9.50E-16 3.5410347 None None 6.20E-12
5 KLRD1 3.36E-20 2.954916 None None 6.58E-16
5 LINC01871 1.98E-09 1.9404677 None None 3.23E-06
5 GZMB 7.76E-11 2.317063 None None 2.17E-07
5 LINC02446 1.46E-10 3.6470053 None None 3.56E-07
5 RPS6 6.38E-11 0.6022945 None None 2.08E-07
5 KLRC4 1.73E-09 2.0416493 None None 3.08E-06
6 CTLA4 1.18E-21 4.052064 None None 2.89E-18
6 IL32 3.45E-23 2.5125043 None None 1.13E-19
6 CARD16 4.59E-14 2.2525911 None None 5.28E-11
6 TIGIT 2.37E-21 3.266728 None None 5.16E-18
6 STAM 2.69E-14 3.8652322 None None 3.29E-11
6 LTB 1.62E-15 2.6679225 None None 2.26E-12
6 FOXP3 7.32E-18 9.159914 None None 1.19E-14
6 TBC1D4 1.51E-17 4.3926163 None None 2.27E-14
6 CORO1B 3.15E-13 2.5346668 None None 3.43E-10
6 S100A4 9.31E-22 2.1557431 None None 2.60E-18
7 CST3 1.51E-22 6.2584434 None None 1.10E-19
7 NAMPT 1.03E-23 4.1905336 None None 1.01E-20
7 PSAP 4.10E-21 3.1675982 None None 2.36E-18
7 CD83 3.10E-23 5.0118585 None None 2.64E-20
7 SIPA1L1 2.28E-21 4.4120255 None None 1.40E-18
7 HLA-DRB1 1.30E-22 3.0379484 None None 9.78E-20
7 PLAUR 1.69E-24 7.2549734 None None 2.07E-21
7 PLXDC2 8.99E-26 6.1526904 None None 1.60E-22
7 IFI30 6.43E-26 6.7624307 None None 1.40E-22
7 SAT1 1.14E-28 3.7164762 None None 4.46E-25
8 MALAT1 2.14E-17 1.2483206 None None 5.75E-15
8 RFTN1 4.39E-13 3.3341734 None None 6.93E-11
8 ATXN1 8.97E-14 3.1262498 None None 1.49E-11
8 SIK3 1.24E-15 3.2614639 None None 2.58E-13
8 VPS13B 1.35E-12 3.4789383 None None 2.02E-10
8 PRKCH 8.11E-16 2.588867 None None 1.76E-13
8 CHST11 5.72E-16 3.4933808 None None 1.30E-13
8 PPP1R16B 1.64E-16 3.455277 None None 3.91E-14
8 RABGAP1L 9.28E-13 2.690405 None None 1.41E-10
8 ANKRD11 3.10E-12 3.3661482 None None 4.44E-10
9 HSP90B1 1.30E-18 4.0922146 None None 4.23E-15
9 DERL3 5.57E-16 8.958008 None None 5.45E-13
9 HERPUD1 1.71E-16 3.479165 None None 2.39E-13
9 JCHAIN 2.57E-18 11.681846 None None 7.19E-15
9 IGHG1 1.84E-19 9.02507 None None 9.00E-16
9 IGLC2 7.61E-21 8.940172 None None 4.97E-17
9 IGHV4-61 7.57E-21 11.205306 None None 4.97E-17
9 IGLV3-1 7.57E-21 11.531429 None None 4.97E-17
9 MZB1 7.13E-15 8.971891 None None 3.58E-12
9 IGHGP 1.24E-13 7.670989 None None 4.33E-11
0 IL7R 2.51E-145 2.2112777 None None 4.93E-141
0 ARHGAP15 4.77E-93 1.21048 None None 2.35E-89
0 GSTK1 1.87E-81 1.2605145 None None 6.13E-78
0 RPLP0 3.16E-77 0.6485295 None None 8.88E-74
0 FXYD5 8.89E-102 0.88010514 None None 5.83E-98
0 LDHB 2.12E-73 1.2445947 None None 5.21E-70
0 RPL28 5.20E-70 0.3845244 None None 1.14E-66
0 VIM 2.38E-136 1.2783217 None None 2.34E-132
0 EEF1A1 2.25E-68 0.42316678 None None 4.43E-65
0 TPT1 5.38E-89 0.55726147 None None 2.12E-85
1 FOS 8.50E-143 3.299096 None None 2.78E-139
1 KLF6 1.12E-155 2.204935 None None 4.40E-152
1 BTG1 3.69E-92 1.0947901 None None 7.26E-89
1 PPP1R15A 3.56E-122 2.4043598 None None 8.75E-119
1 GPR183 4.78E-125 2.4232025 None None 1.34E-121
1 JUN 7.95E-207 3.3718753 None None 1.56E-202
1 DNAJB1 2.44E-187 2.7153752 None None 2.40E-183
1 DUSP1 2.99E-168 2.9106822 None None 1.96E-164
1 TUBA1A 3.40E-101 2.0591981 None None 7.44E-98
1 CD69 2.42E-164 2.3295143 None None 1.19E-160
2 RPL32 2.07E-97 0.62069005 None None 8.13E-94
2 RPS14 5.19E-90 0.55725265 None None 1.28E-86
2 RPL34 3.33E-94 0.5230986 None None 9.36E-91
2 RPS15A 1.74E-99 0.54048795 None None 8.55E-96
2 RPS12 8.20E-101 0.6837594 None None 5.38E-97
2 RPL30 2.40E-116 0.58414495 None None 4.71E-112
2 RPS27A 5.37E-86 0.4821179 None None 1.06E-82
2 RPS3A 3.97E-115 0.6580665 None None 3.91E-111
2 RPS13 4.84E-97 0.6166077 None None 1.58E-93
2 RPS3 2.06E-85 0.5812438 None None 3.68E-82
3 RPS28 2.03E-77 0.57107174 None None 5.71E-74
3 RPS3A 7.20E-88 0.6483365 None None 1.42E-83
3 RPL30 1.65E-82 0.5781324 None None 6.50E-79
3 RPS3 1.36E-75 0.61251014 None None 3.34E-72
3 RPS14 2.14E-81 0.586418 None None 7.02E-78
3 RPS15A 4.14E-83 0.5487287 None None 2.04E-79
3 RPS12 1.95E-69 0.6559366 None None 3.84E-66
3 RPS13 4.36E-70 0.59637195 None None 9.52E-67
3 MT-CYB 1.48E-67 0.5387384 None None 2.65E-64
3 RPL32 1.42E-84 0.64040345 None None 1.40E-80
4 HLA-DQA1 5.71E-196 4.989005 None None 1.60E-192
4 CD37 2.76E-201 2.3092122 None None 1.09E-197
4 HLA-DRA 2.15E-201 5.857147 None None 1.06E-197
4 AFF3 8.38E-182 5.631785 None None 1.83E-178
4 CD74 5.61E-208 5.249994 None None 1.10E-203
4 HLA-DPA1 7.98E-180 4.22183 None None 1.57E-176
4 HLA-DRB1 2.35E-203 5.040215 None None 2.31E-199
4 CD83 2.14E-202 6.011839 None None 1.40E-198
4 HLA-DQB1 5.94E-193 5.0793343 None None 1.46E-189
4 CD79A 2.58E-199 6.066798 None None 8.45E-196
5 PFN1 3.98E-139 1.6963154 None None 7.11E-136
5 CD247 4.45E-164 3.378668 None None 1.75E-160
5 HLA-C 1.15E-136 1.455492 None None 1.50E-133
5 PRF1 2.34E-168 5.595012 None None 1.15E-164
5 GNLY 8.11E-156 6.907666 None None 2.28E-152
5 NKG7 2.39E-174 6.789874 None None 4.66E-170
5 CCL5 2.41E-139 5.5919375 None None 4.73E-136
5 CST7 4.74E-174 5.3132477 None None 4.66E-170
5 GZMA 2.06E-156 5.1676054 None None 6.76E-153
5 GZMB 2.19E-172 5.8165455 None None 1.43E-168
6 HLA-B 7.31E-115 1.1185942 None None 2.40E-111
6 NKG7 4.63E-119 6.0674906 None None 1.82E-115
6 S100A4 1.34E-109 2.6578305 None None 3.70E-106
6 SH3BGRL3 3.58E-106 1.808227 None None 7.82E-103
6 CST7 1.51E-109 4.1388907 None None 3.70E-106
6 CD99 1.74E-103 1.9738711 None None 3.42E-100
6 CCL5 2.87E-124 5.5240245 None None 1.41E-120
6 GZMH 2.50E-149 5.6042433 None None 4.92E-145
6 B2M 7.26E-138 1.1427706 None None 4.76E-134
6 HLA-C 8.78E-140 1.6458231 None None 8.63E-136
7 IFI30 1.17E-147 7.874691 None None 3.84E-144
7 NEAT1 4.91E-144 4.2463756 None None 1.02E-140
7 CST3 7.97E-148 8.222568 None None 3.13E-144
7 TYROBP 1.25E-142 6.1816654 None None 2.23E-139
7 S100A9 9.86E-150 9.510178 None None 4.85E-146
7 FCN1 2.19E-145 8.499745 None None 6.16E-142
7 CTSS 4.83E-145 4.7075863 None None 1.19E-141
7 FTL 1.19E-152 2.8901975 None None 2.35E-148
7 LYZ 4.18E-151 9.573528 None None 4.11E-147
7 S100A8 7.41E-151 10.113356 None None 4.86E-147
8 HLA-DPB1 7.89E-72 3.566425 None None 1.72E-68
8 CD74 5.97E-83 4.7717204 None None 3.92E-79
8 HLA-DQB1 4.20E-72 3.9663408 None None 1.03E-68
8 HLA-DPA1 2.84E-69 3.5505881 None None 5.58E-66
8 HLA-DQA1 1.67E-79 4.1541796 None None 6.56E-76
8 HLA-DRA 1.52E-80 5.079043 None None 7.46E-77
8 BLK 8.48E-74 5.0119877 None None 2.38E-70
8 MS4A1 2.43E-87 5.098299 None None 4.77E-83
8 BANK1 5.33E-86 4.976401 None None 5.24E-82
8 CD79A 7.58E-76 4.572542 None None 2.48E-72
9 CD8B 2.53E-53 5.2773147 None None 1.66E-49
9 CD8A 5.36E-57 5.2543373 None None 5.27E-53
9 CMC1 1.12E-45 3.983456 None None 3.15E-42
9 HLA-B 5.47E-45 0.98704475 None None 1.34E-41
9 LYAR 1.80E-43 3.7170336 None None 3.54E-40
9 CCL5 6.25E-59 5.468395 None None 1.23E-54
9 CST7 4.23E-52 4.1765018 None None 2.08E-48
9 NKG7 1.15E-49 5.4816914 None None 4.53E-46
9 GZMA 1.57E-44 3.7907286 None None 3.43E-41
9 HCST 1.77E-46 2.2789 None None 5.79E-43
10 STAM 1.50E-12 3.3292265 None None 1.41E-09
10 PFN1 1.40E-13 0.7889027 None None 2.30E-10
10 TMSB10 4.77E-14 0.568754 None None 1.34E-10
10 TMSB4X 3.82E-13 0.42634663 None None 4.70E-10
10 IL32 5.40E-23 1.9241086 None None 1.06E-18
10 ARHGDIB 1.56E-12 0.587481 None None 1.41E-09
10 FOXP3 3.58E-12 8.860203 None None 2.62E-09
10 S100A10 8.13E-14 1.3168097 None None 1.78E-10
10 HLA-A 1.61E-12 0.62596434 None None 1.41E-09
10 ANXA2 1.65E-12 1.9809965 None None 1.41E-09
11 CD8B 7.58E-09 3.3541262 None None 0.000149075
11 RPL26 3.91E-08 0.29138806 None None 0.000384392
11 RPS14 1.12E-05 0.32948142 None None 0.024510731
11 KLRC4 2.62E-05 2.740191 None None 0.051530939
11 TRBV24-1 1.09E-06 5.8341036 None None 0.004287207
11 RPL24 3.04E-05 0.32054847 None None 0.054363339
11 IL32 5.60E-06 1.1862634 None None 0.015726962
11 CD8A 8.78E-07 2.490481 None None 0.004287207
11 RPS3 4.24E-07 0.42199552 None None 0.002780016
11 RPS12 3.69E-06 0.4048951 None None 0.012076494
12 DERL3 1.65E-18 8.256556 None None 1.26E-15
12 UBE2J1 1.49E-16 3.9860604 None None 4.96E-14
12 HSP90B1 6.65E-18 3.5495574 None None 3.85E-15
12 MZB1 7.65E-20 8.382848 None None 3.56E-16
12 CD27 9.77E-17 3.8403926 None None 3.62E-14
12 PPIB 6.62E-17 2.761966 None None 2.66E-14
12 JCHAIN 3.45E-21 10.34949 None None 3.63E-17
12 CD79A 3.25E-19 5.6546 None None 5.11E-16
12 ITM2C 3.05E-19 6.062669 None None 5.11E-16
12 SSR4 3.69E-21 3.5578518 None None 3.63E-17
13 IL2RB 3.67E-11 4.8410497 None None 1.20E-07
13 XCL1 1.56E-15 7.1136217 None None 3.07E-11
13 IFITM2 4.29E-12 2.2455692 None None 1.69E-08
13 IFITM3 3.54E-10 3.4651403 None None 6.96E-07
13 CMC1 1.28E-10 4.169739 None None 3.14E-07
13 H3F3B 2.74E-10 1.3768039 None None 5.98E-07
13 GNLY 3.52E-13 6.73575 None None 2.31E-09
13 HOPX 2.24E-13 4.472571 None None 2.21E-09
13 GZMK 7.98E-13 6.675137 None None 3.92E-09
13 KLRC1 7.35E-11 6.961793 None None 2.07E-07
14 CD8A 2.78E-10 4.9565263 None None 1.09E-06
14 CD8B 5.56E-09 4.5659113 None None 1.11E-05
14 NKG7 5.65E-09 5.6439366 None None 1.11E-05
14 TRBV7-5 2.89E-13 9.324483 None None 5.68E-09
14 HLA-C 3.06E-09 1.4422654 None None 8.35E-06
14 TRBV7-6 1.45E-10 7.0643992 None None 7.11E-07
14 TRAV3 8.56E-12 7.5732427 None None 8.42E-08
14 B2M 3.40E-09 0.99904764 None None 8.35E-06
14 KLRD1 1.44E-09 3.8818612 None None 4.71E-06
14 GZMH 8.48E-11 4.9700327 None None 5.56E-07
15 MS4A7 5.80E-12 7.757548 None None 1.78E-08
15 FCER1G 7.46E-12 6.388306 None None 1.78E-08
15 AIF1 5.47E-12 6.2480545 None None 1.78E-08
15 CD68 9.08E-12 6.646105 None None 1.78E-08
15 FTH1 8.11E-12 3.2668579 None None 1.78E-08
15 LST1 4.76E-12 7.174252 None None 1.78E-08
15 SERPINA1 6.90E-12 7.3156815 None None 1.78E-08
15 FCGR3A 9.11E-12 6.3301167 None None 1.78E-08
15 PSAP 7.22E-12 4.798867 None None 1.78E-08
15 IFITM3 6.68E-12 6.681832 None None 1.78E-08
16 APP 1.04E-08 5.6864324 None None 2.54E-05
16 SPIB 1.38E-08 6.3939476 None None 2.54E-05
16 IRF7 1.08E-08 6.2656045 None None 2.54E-05
16 ITM2C 1.05E-08 7.197411 None None 2.54E-05
16 PLD4 9.98E-09 9.051607 None None 2.54E-05
16 CLEC4C 9.79E-09 12.382282 None None 2.54E-05
16 LILRA4 9.70E-09 11.631087 None None 2.54E-05
16 SERPINF1 9.70E-09 11.158938 None None 2.54E-05
16 SEC61B 1.42E-08 3.550174 None None 2.54E-05
16 IGKC 1.53E-08 7.029117 None None 2.54E-05
0 RPS3A 5.62E-89 0.87645334 None None 1.06E-84
0 RPS13 8.66E-78 0.7738425 None None 4.10E-74
0 RPL30 9.83E-88 0.857443 None None 9.30E-84
0 RPL11 7.31E-75 0.80032 None None 2.77E-71
0 RPS23 1.83E-66 0.784089 None None 3.47E-63
0 RPL32 1.61E-72 0.84357446 None None 4.35E-69
0 RPL34 6.62E-74 0.75540817 None None 2.09E-70
0 RPS15A 5.63E-72 0.7603704 None None 1.33E-68
0 RPS12 7.49E-67 0.97172475 None None 1.58E-63
0 RPS14 1.45E-80 0.804537 None None 9.12E-77
1 CST7 7.87E-118 6.0822873 None None 2.48E-114
1 GZMB 9.00E-125 8.009166 None None 5.68E-121
1 CD7 1.45E-120 4.1575823 None None 5.49E-117
1 KLRB1 8.30E-106 5.0793986 None None 1.96E-102
1 CTSW 1.45E-123 5.6198587 None None 6.87E-120
1 HLA-C 1.81E-102 1.3509313 None None 3.11E-99
1 FGFBP2 4.16E-108 7.2036853 None None 1.12E-104
1 CD247 5.54E-101 3.5199487 None None 8.73E-98
1 GNLY 7.02E-129 8.155408 None None 6.64E-125
1 NKG7 4.09E-133 7.947705 None None 7.74E-129
2 RPS29 1.09E-34 0.7827201 None None 2.29E-31
2 RPLP0 2.08E-34 0.7685144 None None 3.65E-31
2 LDHB 3.62E-35 1.5481172 None None 1.14E-31
2 TPT1 6.18E-35 0.5280897 None None 1.58E-31
2 RPL36 4.24E-40 0.7833499 None None 2.00E-36
2 IL32 5.05E-41 2.2458375 None None 3.18E-37
2 RPS18 3.26E-45 0.8764736 None None 3.09E-41
2 RPL23A 2.77E-38 0.71997595 None None 1.05E-34
2 LTB 6.68E-35 1.89922 None None 1.58E-31
2 IL7R 1.78E-49 2.5185404 None None 3.37E-45
3 S100A9 1.47E-115 8.743644 None None 2.78E-111
3 VCAN 1.84E-108 7.5036645 None None 6.96E-105
3 FTL 1.09E-102 2.86229 None None 1.73E-99
3 CTSS 2.91E-107 4.6273723 None None 7.88E-104
3 S100A8 3.90E-113 8.823406 None None 2.46E-109
3 LYZ 1.61E-114 8.349073 None None 1.52E-110
3 S100A12 4.63E-103 9.060777 None None 7.97E-100
3 TKT 8.73E-107 3.9082205 None None 2.06E-103
3 FCN1 1.34E-107 6.7497897 None None 4.22E-104
3 S100A6 7.87E-106 3.6314807 None None 1.65E-102
4 CD3E 1.09E-15 1.6274244 None None 4.13E-12
4 RPLP0 2.17E-10 0.5282973 None None 3.16E-07
4 B2M 3.33E-15 0.52997816 None None 9.01E-12
4 IL32 1.18E-21 2.0893369 None None 2.23E-17
4 RORA 1.50E-15 1.7493812 None None 4.73E-12
4 CD52 1.70E-17 1.152103 None None 1.19E-13
4 CCL5 1.03E-15 2.767998 None None 4.13E-12
4 CD3D 1.54E-11 1.4759442 None None 2.65E-08
4 RPS19 1.89E-17 0.5699146 None None 1.19E-13
4 LYAR 2.22E-12 2.2703052 None None 5.26E-09
5 CD37 1.65E-57 2.08052 None None 5.22E-54
5 BANK1 2.18E-49 7.153289 None None 4.12E-46
5 MS4A1 4.30E-70 8.915348 None None 8.14E-66
5 HLA-DPB1 9.20E-50 3.664102 None None 1.93E-46
5 CD79A 1.12E-67 7.807917 None None 1.06E-63
5 CD74 4.14E-63 4.2262626 None None 2.61E-59
5 EZR 4.60E-53 3.2247462 None None 1.24E-49
5 HLA-DRA 2.20E-51 4.5549164 None None 5.21E-48
5 LAPTM5 1.53E-57 1.976506 None None 5.22E-54
5 HLA-DQB1 2.03E-58 4.1468525 None None 9.62E-55
6 RPL32 3.54E-19 0.7124596 None None 8.37E-16
6 RPL30 2.37E-25 0.76759595 None None 4.47E-21
6 RPS3 3.65E-20 0.79766 None None 9.88E-17
6 RPS15A 2.80E-20 0.6718685 None None 8.84E-17
6 RPS12 4.41E-19 0.8394096 None None 8.57E-16
6 RPS28 5.65E-25 0.6846366 None None 5.34E-21
6 RPL11 1.16E-20 0.69621104 None None 4.41E-17
6 RPS3A 1.30E-21 0.72159636 None None 8.23E-18
6 RPL19 3.85E-21 0.66388214 None None 1.82E-17
6 RPL35A 4.53E-19 0.62362576 None None 8.57E-16
7 AIF1 1.20E-32 4.765202 None None 1.14E-28
7 HLA-DRA 1.96E-30 5.0203176 None None 4.13E-27
7 COTL1 2.61E-32 3.556084 None None 1.64E-28
7 LST1 1.12E-30 4.790188 None None 2.65E-27
7 HLA-DRB1 2.46E-30 4.7843356 None None 4.66E-27
7 CST3 8.09E-35 5.9356055 None None 1.53E-30
7 HLA-DPA1 7.65E-32 4.633556 None None 2.07E-28
7 FTL 4.25E-32 2.8219476 None None 2.01E-28
7 IFI30 6.70E-32 5.3889246 None None 2.07E-28
7 NPC2 5.56E-32 3.3884468 None None 2.07E-28
8 IL32 6.45E-19 3.2280726 None None 1.22E-14
8 TMSB10 5.74E-09 0.7033607 None None 1.55E-05
8 CD3D 2.25E-08 1.9716636 None None 4.73E-05
8 CD3E 3.29E-09 1.8751713 None None 1.04E-05
8 CD52 1.59E-16 1.853472 None None 1.50E-12
8 HLA-A 3.03E-11 1.0226663 None None 1.43E-07
8 ARID5B 1.73E-09 2.4899092 None None 6.54E-06
8 S100A10 3.19E-08 1.4241984 None None 6.04E-05
8 B2M 3.86E-13 0.81269616 None None 2.43E-09
8 PTPRCAP 1.38E-08 1.4979641 None None 3.26E-05
9 SSR2 0.002731384 0.97261494 None None 1
9 SMARCA5 0.000158123 1.9254454 None None 1
9 PMAIP1 0.001891249 1.5407941 None None 1
9 XBP1 0.000299077 1.6293418 None None 1
9 SSR3 0.002846649 1.438412 None None 1
9 RPLP0 0.001175886 0.6154208 None None 1
9 GATA3 0.000588037 2.268307 None None 1
9 ISG20 0.002199711 1.3481435 None None 1
9 FKBP11 6.16E-05 1.966229 None None 1
9 PBX4 0.00242081 1.6786324 None None 1
10 IGKV4-1 2.62E-09 10.275751 None None 4.01E-05
10 FCER2 8.04E-07 6.274424 None None 0.001521165
10 TCF4 9.05E-08 5.465468 None None 0.000285503
10 CD37 8.79E-09 2.4452133 None None 5.54E-05
10 CD74 3.31E-08 4.0078645 None None 0.000125354
10 CD79A 4.24E-09 5.3307395 None None 4.01E-05
10 IRF8 2.06E-08 3.8722181 None None 9.75E-05
10 FCMR 1.27E-07 3.6891859 None None 0.000344304
10 LAPTM5 4.06E-07 1.6235116 None None 0.000852526
10 ADAM28 1.76E-07 4.930439 None None 0.000417269
11 RPL9 5.86E-07 0.96369505 None None 0.002219325
11 RPL32 2.17E-06 0.8850769 None None 0.004567422
11 RPL22 1.67E-06 0.9102057 None None 0.00421081
11 RPS6 1.05E-06 1.0396904 None None 0.003314688
11 RPS3A 4.61E-07 0.94154793 None None 0.00217967
11 RPL3 3.40E-07 1.1388178 None None 0.002143557
11 CD8B 4.12E-09 7.00114 None None 3.89E-05
11 LINC02446 3.17E-09 8.152682 None None 3.89E-05
11 RPS9 3.25E-06 0.8908142 None None 0.006143139
11 RPS12 4.15E-06 0.9840155 None None 0.007136051
0 KLRD1 1.36E-52 4.364563 None None 2.31E-48
0 KLRF1 2.65E-45 4.423493 None None 4.50E-42
0 PRF1 7.89E-46 4.420697 None None 1.67E-42
0 CD7 3.71E-46 2.7904139 None None 9.00E-43
0 HOPX 3.20E-46 4.1623616 None None 9.00E-43
0 NKG7 5.56E-47 5.1364713 None None 1.88E-43
0 SPON2 5.97E-48 4.7731037 None None 2.53E-44
0 GZMB 2.97E-49 4.7213893 None None 1.68E-45
0 GNLY 5.99E-51 5.707302 None None 5.08E-47
0 ZFP36 3.73E-45 2.760976 None None 5.53E-42
1 NAMPT 2.28E-61 6.5459337 None None 3.01E-58
1 IFI30 3.72E-65 8.6401205 None None 3.16E-61
1 LYZ 1.16E-62 9.03827 None None 3.28E-59
1 S100A9 7.95E-66 8.915977 None None 1.35E-61
1 AIF1 3.18E-62 6.302813 None None 7.72E-59
1 LGALS3 1.80E-61 6.3386064 None None 3.01E-58
1 SAT1 1.02E-63 4.327248 None None 4.34E-60
1 S100A8 2.19E-61 9.837839 None None 3.01E-58
1 CST3 6.43E-64 8.814244 None None 3.64E-60
1 FTH1 1.01E-61 3.0582314 None None 2.15E-58
2 RPS18 1.51E-17 0.6954782 None None 2.32E-14
2 RPL32 6.43E-19 0.51714724 None None 1.36E-15
2 LEF1 7.75E-17 2.1566038 None None 9.39E-14
2 APOO 4.26E-18 0.9316046 None None 7.22E-15
2 RPS3A 2.07E-17 0.5300557 None None 2.93E-14
2 NDFIP1 7.82E-21 1.8346488 None None 3.32E-17
2 RPS25 1.65E-19 0.6549677 None None 5.61E-16
2 SARAF 8.64E-17 1.027354 None None 9.71E-14
2 IL7R 4.22E-24 2.4419491 None None 3.58E-20
2 RPS8 2.54E-17 0.5967577 None None 3.31E-14
3 IL32 5.39E-14 1.8199782 None None 1.31E-10
3 IL7R 7.62E-15 1.9729218 None None 6.46E-11
3 RPS19 1.68E-12 0.6983155 None None 3.16E-09
3 RPL18A 1.23E-13 0.6639751 None None 2.60E-10
3 TPT1 4.35E-14 0.6650598 None None 1.23E-10
3 RPL36A 2.17E-14 0.78471667 None None 7.38E-11
3 RPS18 1.82E-14 0.87945944 None None 7.38E-11
3 RPL13A 2.31E-12 0.74741006 None None 3.92E-09
3 LTB 2.76E-15 1.9631588 None None 4.67E-11
3 LDHB 1.58E-14 1.3791918 None None 7.38E-11
4 RPS5 8.97E-20 1.0001582 None None 1.69E-16
4 RPL34 1.43E-23 0.6844031 None None 2.42E-19
4 EEF1A1 4.39E-20 0.7018286 None None 9.31E-17
4 RPS6 4.13E-20 0.90178823 None None 9.31E-17
4 RPS3A 6.04E-21 0.7379436 None None 1.71E-17
4 RPS12 1.26E-19 0.8399196 None None 2.14E-16
4 RPL11 2.70E-22 0.7292095 None None 1.52E-18
4 RPL30 1.62E-19 0.65112835 None None 2.49E-16
4 TPT1 4.13E-22 0.7992853 None None 1.75E-18
4 RPL13 1.14E-21 0.8753029 None None 3.88E-18
5 RPS15A 6.59E-20 0.65838724 None None 1.40E-16
5 RPL32 2.33E-23 0.80885607 None None 1.98E-19
5 RPL22 1.41E-20 0.7967931 None None 3.42E-17
5 RPL11 4.68E-23 0.73111933 None None 2.64E-19
5 RPL30 9.09E-24 0.6592206 None None 1.54E-19
5 RPL34 5.43E-19 0.63680226 None None 9.20E-16
5 RPL19 1.08E-21 0.65235656 None None 3.67E-18
5 RPS3A 3.09E-21 0.69658417 None None 8.74E-18
5 RPL39 2.52E-22 0.73921293 None None 1.07E-18
5 RPS13 2.75E-19 0.68425626 None None 5.18E-16
6 B2M 3.71E-36 0.8834058 None None 2.10E-32
6 GZMH 2.03E-45 5.114775 None None 3.45E-41
6 GZMA 4.09E-29 3.3462749 None None 7.71E-26
6 NKG7 1.15E-33 5.0129156 None None 4.87E-30
6 HLA-B 3.22E-29 0.9358959 None None 6.82E-26
6 CTSW 1.58E-30 3.0270524 None None 3.83E-27
6 FGFBP2 1.77E-32 4.13854 None None 6.00E-29
6 CST7 1.03E-30 3.6147432 None None 2.91E-27
6 GNLY 7.41E-28 4.6362963 None None 1.26E-24
6 CCL5 1.77E-39 4.757439 None None 1.50E-35
7 CXCR4 1.66E-10 1.5376891 None None 3.52E-07
7 CD8B 3.73E-13 3.8231347 None None 1.27E-09
7 PIK3R1 4.31E-10 1.5859394 None None 7.32E-07
7 LYAR 6.11E-11 2.4015737 None None 1.73E-07
7 HERPUD1 3.19E-10 1.9766296 None None 6.01E-07
7 CD74 1.24E-10 1.6062396 None None 3.00E-07
7 CCL5 1.13E-14 3.4674582 None None 4.77E-11
7 GZMK 8.67E-17 4.9380703 None None 4.90E-13
7 DUSP2 2.62E-18 3.0250275 None None 2.22E-14
7 CD8A 2.60E-18 3.7418184 None None 2.22E-14
8 RPL4 0.000624818 1.1129669 None None 1
8 P2RY8 0.003069797 1.9722375 None None 1
8 TPT1 0.003032494 0.82129604 None None 1
8 RAB6A 0.002944646 2.163459 None None 1
8 IKBKE 0.003735364 2.8341668 None None 1
8 EEF1G 0.002887378 1.030585 None None 1
8 AC079793.1 0.002655157 3.136527 None None 1
8 HINT1 0.001601522 1.2146907 None None 1
8 SMIM20 0.003441459 2.9384484 None None 1
8 RPS18 0.003826049 1.0241289 None None 1
9 HLA-DRA 8.75E-06 6.1749983 None None 0.02749053
9 HLA-DPB1 1.30E-05 4.6975446 None None 0.02749053
9 HLA-DQB1 1.16E-05 5.152171 None None 0.02749053
9 HLA-DPA1 1.06E-05 4.8336716 None None 0.02749053
9 ARHGAP24 8.62E-06 6.2782955 None None 0.02749053
9 CD79A 5.48E-06 9.925275 None None 0.02749053
9 NIBAN3 5.11E-06 31.677961 None None 0.02749053
9 CD74 5.11E-06 5.221729 None None 0.02749053
9 CD37 2.42E-05 2.3476336 None None 0.045564768
9 CYB561A3 2.69E-05 4.2174163 None None 0.045630368



SkewC Quality Control Output Plots


Select Run

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Gene Body Coverage of All Cells.

Select Run

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Gene Body Coverage of Typical Cells.

Select Run

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Gene Body Coverage of Skewed Cells.

Select Run

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Cell CLustering Result.

Select Run

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Mean Gene Body Coverage.