##FastQC	0.11.5
>>Basic Statistics	pass
#Measure	Value
Filename	SRR2920918_2.fastq
File type	Conventional base calls
Encoding	Sanger / Illumina 1.9
Total Sequences	2824633
Sequences flagged as poor quality	0
Sequence length	125
%GC	47
>>END_MODULE
>>Per base sequence quality	pass
#Base	Mean	Median	Lower Quartile	Upper Quartile	10th Percentile	90th Percentile
1	29.43066515189761	31.0	30.0	34.0	23.0	34.0
2	29.512189725178455	31.0	30.0	34.0	23.0	34.0
3	29.577529186977564	31.0	30.0	34.0	23.0	34.0
4	32.91230506759639	37.0	35.0	37.0	25.0	37.0
5	33.02664629351848	37.0	35.0	37.0	26.0	37.0
6	32.95483200826444	37.0	35.0	37.0	25.0	37.0
7	32.9085898946872	37.0	35.0	37.0	25.0	37.0
8	32.816822220798244	37.0	35.0	37.0	25.0	37.0
9	34.15665964392542	39.0	35.0	39.0	23.0	39.0
10-11	34.18610718631412	39.0	35.0	39.0	24.0	39.0
12-13	34.12821860397439	39.0	35.0	39.0	23.0	39.0
14-15	35.25325148435213	40.0	36.0	41.0	23.5	41.0
16-17	35.24813648357149	40.0	35.5	41.0	24.0	41.0
18-19	35.23904804624176	40.0	35.0	41.0	24.0	41.0
20-21	35.275060335271874	40.0	35.0	41.0	24.0	41.0
22-23	35.20308390505953	40.0	35.0	41.0	24.0	41.0
24-25	35.21490278560082	40.0	35.0	41.0	24.0	41.0
26-27	35.146112610027565	40.0	35.0	41.0	24.0	41.0
28-29	35.025276027009525	40.0	35.0	41.0	24.0	41.0
30-31	34.85980621199285	39.5	34.0	41.0	23.5	41.0
32-33	34.70662560410503	39.0	34.0	41.0	22.5	41.0
34-35	34.61594780631678	39.0	34.0	41.0	21.5	41.0
36-37	34.45883925451554	39.0	34.0	41.0	19.5	41.0
38-39	34.3058321204914	39.0	34.0	41.0	18.0	41.0
40-41	34.1596141870466	39.0	33.5	41.0	17.0	41.0
42-43	33.95382143450141	39.0	33.0	41.0	15.5	41.0
44-45	33.78260485521482	39.0	33.0	41.0	14.5	41.0
46-47	33.55839979919516	38.0	33.0	41.0	9.5	41.0
48-49	33.40956453457848	38.0	33.0	40.0	8.5	41.0
50-51	33.198250356772014	38.0	32.5	40.0	7.5	41.0
52-53	32.99216305268685	38.0	32.0	40.0	4.0	41.0
54-55	32.74202648627273	38.0	32.0	40.0	2.0	41.0
56-57	32.46957675563516	37.5	31.0	40.0	2.0	41.0
58-59	32.19772073044534	37.0	31.0	40.0	2.0	41.0
60-61	31.91361160901257	36.5	31.0	40.0	2.0	41.0
62-63	31.590457415175706	36.0	31.0	39.5	2.0	41.0
64-65	31.29204183339924	35.5	30.0	39.0	2.0	41.0
66-67	30.936675844260122	35.0	30.0	39.0	2.0	40.5
68-69	30.60942288785835	35.0	30.0	38.0	2.0	40.0
70-71	30.26459331176829	35.0	29.0	37.5	2.0	40.0
72-73	30.321050557718472	35.0	30.0	37.0	2.0	39.5
74-75	30.323408386151407	35.0	30.0	37.0	2.0	39.0
76-77	30.066170012175036	35.0	30.0	36.5	2.0	39.0
78-79	29.786618650989347	35.0	30.0	36.0	2.0	38.5
80-81	29.529587206550374	35.0	30.0	35.5	2.0	37.0
82-83	29.305101229080023	35.0	30.0	35.0	2.0	37.0
84-85	29.082405926716852	35.0	30.0	35.0	2.0	36.5
86-87	28.902790380201605	35.0	29.0	35.0	2.0	36.0
88-89	28.714535835274884	34.0	29.0	35.0	2.0	36.0
90-91	28.556989173460764	34.0	29.0	35.0	2.0	36.0
92-93	28.400748345006235	34.0	29.0	35.0	2.0	35.0
94-95	28.29935446481012	34.0	29.0	35.0	2.0	35.0
96-97	28.217409836959348	34.0	29.0	35.0	2.0	35.0
98-99	28.093340798609944	34.0	29.0	35.0	2.0	35.0
100-101	27.981555125922554	34.0	29.0	35.0	2.0	35.0
102-103	26.650543982173968	32.5	25.5	34.5	2.0	35.0
104-105	27.66309534725396	34.0	27.5	35.0	2.0	35.0
106-107	27.821545666286557	34.0	29.0	35.0	2.0	35.0
108-109	27.76634238855101	34.0	28.5	35.0	2.0	35.0
110-111	27.67718053991439	34.0	28.0	35.0	2.0	35.0
112-113	27.56643022297056	34.0	27.0	35.0	2.0	35.0
114-115	27.45821740381848	34.0	27.0	35.0	2.0	35.0
116-117	27.252603258547218	34.0	27.0	35.0	2.0	35.0
118-119	27.05959641482628	34.0	27.0	35.0	2.0	35.0
120-121	26.891723101726843	34.0	26.0	35.0	2.0	35.0
122-123	26.617675818416057	34.0	25.0	35.0	2.0	35.0
124-125	25.38432444144071	32.5	21.5	34.5	2.0	35.0
>>END_MODULE
>>Per sequence quality scores	pass
#Quality	Count
2	126298.0
3	17811.0
4	12084.0
5	12570.0
6	17592.0
7	17519.0
8	15452.0
9	16288.0
10	17522.0
11	18595.0
12	18693.0
13	18572.0
14	19591.0
15	17549.0
16	13393.0
17	12047.0
18	11443.0
19	11284.0
20	11631.0
21	12395.0
22	14819.0
23	19073.0
24	26244.0
25	33373.0
26	37364.0
27	39586.0
28	46158.0
29	54697.0
30	64332.0
31	77949.0
32	98289.0
33	125929.0
34	168873.0
35	248326.0
36	442009.0
37	675733.0
38	233130.0
39	420.0
>>END_MODULE
>>Per base sequence content	fail
#Base	G	A	T	C
1	44.14465880500635	18.54961764387778	12.275750306292696	25.029973244823168
2	16.031006344785332	20.777612012264125	38.556057894393504	24.635323748557035
3	19.051421945065524	25.203508628836786	28.935868406914416	26.80920101918327
4	13.053196958147945	16.799886550972293	35.4780990197295	34.66881747115026
5	13.764378047067934	38.20113591713819	33.77800252772769	14.256483508066175
6	32.57610285075144	36.6134683280161	16.7148064850183	14.095622336214161
7	27.5983884732173	33.36280758358874	20.873049737885907	18.16575420530806
8	25.866665249229708	35.90364263579489	19.62958828771844	18.60010382725696
9	26.05646430776187	16.846479822582463	18.994066945494005	38.10298892416166
10-11	24.840239034648683	27.026452907941895	27.218166066363477	20.915141991045942
12-13	25.260456847980993	24.653794474210294	27.092171192660388	22.99357748514832
14-15	22.897421089739275	26.020917552107875	24.481064726077147	26.600596632075707
16-17	22.91378879698995	28.501671363964082	25.480638926925874	23.10390091212009
18-19	22.943354701475457	27.544868492748837	27.045343589663652	22.466433216112055
20-21	24.013651183115524	26.872201983945494	26.5405583686032	22.573588464335778
22-23	23.61777315542797	26.568996304993377	26.3287022064124	23.484528333166253
24-25	23.23486735645279	26.701031986918434	26.580482368511294	23.483618288117487
26-27	23.134635445774908	26.80149655364336	26.58758170826132	23.47628629232041
28-29	23.196921283245022	27.040570057155573	26.564205737379837	23.198302922219572
30-31	23.409078832235735	26.95410279754714	26.366872960823002	23.26994540939412
32-33	23.00194344746784	27.06249270387908	26.42225864697722	23.513305201675855
34-35	23.29746627809509	27.146514298994635	26.399130461276403	23.15688896163387
36-37	23.396128551340432	26.830863885669785	26.42639078482272	23.34661677816706
38-39	23.238560547646163	26.961239395564206	26.41332398766641	23.386876069123215
40-41	23.335740156618296	26.970208653155623	26.47978002721671	23.21427116300937
42-43	23.212952071878014	26.931278697352756	26.400094240689302	23.455674990079928
44-45	23.197571733567337	27.061811432768952	26.346127514808675	23.39448931885504
46-47	23.073544022209	27.097623493106802	26.334592063006507	23.494240421677688
48-49	23.08918477858514	27.10608282038321	26.186509692180334	23.618222708851317
50-51	23.03691490034396	27.22775232213716	26.17545988863519	23.559872888883692
52-53	23.144020107445172	27.01636829641123	26.12196603768906	23.717645558454535
54-55	23.042783216176264	27.064194751446045	26.032905533645494	23.86011649873219
56-57	23.120396445509467	27.076472986871003	25.9469979448631	23.856132622756434
58-59	23.091671228829778	26.80221087944395	26.116000148067357	23.990117743658917
60-61	23.178107747333097	26.696589002505355	26.286191631429183	23.83911161873236
62-63	23.151433288468066	26.70976424392463	26.321439698550762	23.817362769056537
64-65	23.11907028938688	26.7115220582401	26.169506126659186	23.99990152571383
66-67	23.218333555915073	26.835280894020507	26.077416644319936	23.868968905744488
68-69	23.52698199358303	26.494361857811338	26.137025046168255	23.84163110243738
70-71	23.24682255268056	26.452529001695545	26.270026920119737	24.030621525504152
72-73	23.3312505401802	26.522086108619785	26.216804598580584	23.92985875261943
74-75	23.247933215363766	26.582170419205227	26.243493504973088	23.92640286045792
76-77	23.327049936180003	26.28090788416963	26.437685787394923	23.954356392255445
78-79	23.410356146749244	26.377428021699984	26.350240165302168	23.861975666248604
80-81	23.466995961392886	26.32282006076508	26.345951456658035	23.864232521184
82-83	23.37597445429497	26.239433596116278	26.45821864476549	23.92637330482326
84-85	23.448710495747353	26.309439927108585	26.273235112718478	23.96861446442558
86-87	23.339953928591797	26.159232931953103	26.39724138321911	24.10357175623599
88-89	23.443682968671574	26.068985525111877	26.331452019410374	24.155879486806185
90-91	23.525124426575037	26.161603995819977	26.244531429887175	24.06874014771781
92-93	23.53661908146384	26.086234992843888	26.358682609595828	24.01846331609644
94-95	23.318763493722013	26.09463765310155	26.414740754923987	24.171858098252454
96-97	23.377353631975712	26.012939729240454	26.37566089776898	24.234045741014853
98-99	23.270955178120076	26.2632187425618	26.235750535550338	24.230075543767782
100-101	23.201168267704166	26.408467603186388	26.259636021422256	24.130728107687194
102-103	22.988152173258573	26.444993194344242	26.33209687513614	24.23475775726105
104-105	22.936750887132394	26.665044522198766	26.110681962993148	24.2875226276757
106-107	22.897445456823732	26.69549423817549	26.196717624107478	24.21034268089331
108-109	22.871607117808832	26.78056799649749	26.233937960749753	24.113886924943927
110-111	22.90508997473017	27.031297075398392	26.04317533032594	24.020437619545497
112-113	22.971094774671375	27.152597520486232	25.99126971686358	23.885037987978812
114-115	22.926649119513122	27.22518217275326	25.912280763903407	23.935887943830213
116-117	22.912511812495072	27.133622235743303	25.964355713085013	23.989510238676612
118-119	22.99941337380204	27.068211590685117	25.842584385966035	24.089790649546817
120-121	23.05917677400934	27.120274794790404	25.9373804977246	23.883167933475658
122-123	23.141906671753524	27.18960694108066	25.792563198712276	23.875923188453545
124-125	23.268710524488455	27.23523330673881	25.5755967117262	23.920459457046533
>>END_MODULE
>>Per sequence GC content	warn
#GC Content	Count
0	2817.0
1	2079.5
2	1079.0
3	744.5
4	595.5
5	505.5
6	482.5
7	524.5
8	640.5
9	701.0
10	689.0
11	726.5
12	806.5
13	892.5
14	1039.5
15	1219.5
16	1401.5
17	1601.0
18	1901.5
19	2308.5
20	2820.0
21	3526.5
22	4473.0
23	5756.5
24	7331.0
25	9395.5
26	12280.5
27	15640.5
28	18699.0
29	22624.0
30	26970.0
31	31493.5
32	36471.0
33	39925.5
34	42831.5
35	46141.5
36	50917.0
37	55928.0
38	60736.5
39	65991.5
40	71028.5
41	76086.0
42	80773.5
43	87285.0
44	93610.0
45	98920.0
46	103999.0
47	107665.0
48	111982.0
49	115421.5
50	118074.5
51	117954.0
52	113351.5
53	110606.0
54	108930.0
55	104199.5
56	96824.0
57	88038.0
58	80943.5
59	72076.5
60	60411.5
61	50428.0
62	41165.0
63	31409.0
64	23340.5
65	17977.5
66	13728.0
67	10573.0
68	8115.5
69	6230.0
70	4971.5
71	3885.5
72	3051.5
73	2573.0
74	2079.0
75	1634.5
76	1189.5
77	766.5
78	523.0
79	358.5
80	251.5
81	176.0
82	128.0
83	109.5
84	84.0
85	59.5
86	55.5
87	42.5
88	29.5
89	27.0
90	25.0
91	21.5
92	15.5
93	11.0
94	12.0
95	12.0
96	16.5
97	16.5
98	10.0
99	10.5
100	24.0
>>END_MODULE
>>Per base N content	pass
#Base	N-Count
1	0.16349026581506343
2	0.14334605593009783
3	0.16738457704062792
4	0.1410094691947591
5	0.16671192328348497
6	0.10588986250603175
7	0.10482777762633234
8	0.09339266375490196
9	0.09965896454512853
10-11	0.08666612618347233
12-13	0.07577975616655332
14-15	0.07516020665339532
16-17	0.07392110762707935
18-19	0.07261120294211673
20-21	0.06634490215189018
22-23	0.05784822311429485
24-25	0.06121149190000967
26-27	0.07131899967181576
28-29	0.06721227147031136
30-31	0.06383130126993489
32-33	0.07333696094324467
34-35	0.07034542186542464
36-37	0.07335466235790633
38-39	0.06848677332595067
40-41	0.07441674723760573
42-43	0.07339006518722964
44-45	0.06650421488384509
46-47	0.06420303097782969
48-49	0.05607808164812915
50-51	0.06190184707181429
52-53	0.06365428712331832
54-55	0.06568994980940887
56-57	0.06903551718046202
58-59	0.05641440852670064
60-61	0.06659272195715336
62-63	0.06147701311993452
64-65	0.055263816573692934
66-67	0.060184809849633564
68-69	0.06393750975790483
70-71	0.05846777262745284
72-73	0.0531396468142941
74-75	0.056237394380084064
76-77	0.06549523424813064
78-79	0.059529857507152256
80-81	0.057706611797001595
82-83	0.06269841073158886
84-85	0.06386670409925821
86-87	0.0574941948210617
88-89	0.05685694389324206
90-91	0.05958296175113723
92-93	0.053865404815422034
94-95	0.0634595715620401
96-97	0.049209932759406265
98-99	0.04846647334361668
100-101	0.04628919934023287
102-103	0.04411192533684907
104-105	0.042837423481209766
106-107	0.054007016132715295
108-109	0.05370609208346712
110-111	0.06023791409361853
112-113	0.060202511264295225
114-115	0.06241518809700233
116-117	0.0665750205424917
118-119	0.06057424097219001
120-121	0.061122984826701386
122-123	0.05919353062858077
124-125	0.07069945015865778
>>END_MODULE
>>Sequence Length Distribution	pass
#Length	Count
125	2824633.0
>>END_MODULE
>>Sequence Duplication Levels	fail
#Total Deduplicated Percentage	47.802065541841536
#Duplication Level	Percentage of deduplicated	Percentage of total
1	69.97500874375937	33.44949954260121
2	13.371868213366367	12.784058415044134
3	6.086339530445228	8.728188034327315
4	3.191985192108006	6.103339414469382
5	1.9200477663711732	4.5891124585770635
6	1.2930451389729922	3.7086137089047946
7	0.868842541779032	2.9072727689363034
8	0.6200160478890787	2.371043820654984
9	0.46734091650437765	2.01058750090139
>10	2.079934181679752	16.846946937477128
>50	0.09221314815440432	2.9968657635349145
>100	0.03149696351726009	2.551861503459704
>500	0.001340363126101386	0.4384669156084556
>1k	5.212523267651712E-4	0.5141432155033402
>5k	0.0	0.0
>10k+	0.0	0.0
>>END_MODULE
>>Overrepresented sequences	warn
#Sequence	Count	Percentage	Possible Source
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	3344	0.11838706125716154	No Hit
>>END_MODULE
>>Adapter Content	fail
#Position	Illumina Universal Adapter	Illumina Small RNA 3' Adapter	Illumina Small RNA 5' Adapter	Nextera Transposase Sequence	SOLID Small RNA Adapter
1	0.0	0.0	0.0	0.0	0.0
2	0.0	0.0	0.0	0.0	0.0
3	0.0	0.0	0.0	0.0	0.0
4	0.0	0.0	0.0	0.0	0.0
5	0.0	0.0	0.0	0.0	0.0
6	0.0	0.0	0.0	0.0	0.0
7	0.0	0.0	0.0	0.0	0.0
8	0.0	0.0	0.0	0.0	0.0
9	0.0	0.0	0.0	0.0	0.0
10-11	0.0	0.0	0.0	0.0	0.0
12-13	0.0	0.0	0.0	3.5402829323313864E-5	1.7701414661656932E-5
14-15	0.0	0.0	0.0	3.5402829323313864E-5	3.5402829323313864E-5
16-17	0.0	0.0	0.0	3.5402829323313864E-5	3.5402829323313864E-5
18-19	0.0	0.0	0.0	8.850707330828467E-5	3.5402829323313864E-5
20-21	0.0	0.0	0.0	2.1241697593988315E-4	7.080565864662773E-5
22-23	0.0	0.0	0.0	5.133410251880509E-4	7.080565864662773E-5
24-25	0.0	0.0	0.0	0.0012213976116543282	7.080565864662773E-5
26-27	0.0	0.0	0.0	0.002602107955263569	7.080565864662773E-5
28-29	0.0	0.0	0.0	0.007169072937971057	7.080565864662773E-5
30-31	0.0	0.0	0.0	0.025507738527447636	7.080565864662773E-5
32-33	0.0	0.0	0.0	0.06742468844625124	7.080565864662773E-5
34-35	0.0	0.0	0.0	0.12992838361656187	7.080565864662773E-5
36-37	0.0	0.0	0.0	0.23374718060717975	7.080565864662773E-5
38-39	0.0	0.0	0.0	0.39121896543727985	7.080565864662773E-5
40-41	0.0	0.0	0.0	0.5597895372602388	7.080565864662773E-5
42-43	0.0	0.0	0.0	0.7191376720444744	7.080565864662773E-5
44-45	0.0	0.0	0.0	0.9032854887696915	7.080565864662773E-5
46-47	0.0	0.0	0.0	1.1282881705340126	7.080565864662773E-5
48-49	0.0	0.0	0.0	1.3617521285066059	7.080565864662773E-5
50-51	0.0	0.0	0.0	1.5994821274126587	7.080565864662773E-5
52-53	0.0	0.0	0.0	1.831706986358936	1.0620848796994158E-4
54-55	3.5402829323313864E-5	0.0	0.0	2.0885899159289014	1.0620848796994158E-4
56-57	3.5402829323313864E-5	1.7701414661656932E-5	0.0	2.3947004796729345	1.0620848796994158E-4
58-59	5.3104243984970795E-5	3.5402829323313864E-5	0.0	2.71845935383464	1.0620848796994158E-4
60-61	7.080565864662773E-5	3.5402829323313864E-5	0.0	3.054290592795595	1.0620848796994158E-4
62-63	7.080565864662773E-5	3.5402829323313864E-5	0.0	3.3859442978963994	1.0620848796994158E-4
64-65	7.080565864662773E-5	3.5402829323313864E-5	0.0	3.738255553907357	1.0620848796994158E-4
66-67	7.080565864662773E-5	3.5402829323313864E-5	0.0	4.146184654785241	1.0620848796994158E-4
68-69	7.080565864662773E-5	3.5402829323313864E-5	0.0	4.606740061452231	1.0620848796994158E-4
70-71	7.080565864662773E-5	3.5402829323313864E-5	0.0	5.094555646698173	1.0620848796994158E-4
72-73	7.080565864662773E-5	3.5402829323313864E-5	0.0	5.575981021251256	1.0620848796994158E-4
74-75	7.080565864662773E-5	3.5402829323313864E-5	0.0	6.066239401720507	1.0620848796994158E-4
76-77	7.080565864662773E-5	3.5402829323313864E-5	0.0	6.606999918219464	1.0620848796994158E-4
78-79	7.080565864662773E-5	3.5402829323313864E-5	0.0	7.203272071097379	1.0620848796994158E-4
80-81	7.080565864662773E-5	3.5402829323313864E-5	0.0	7.831389068951612	1.0620848796994158E-4
82-83	7.080565864662773E-5	3.5402829323313864E-5	0.0	8.478535087567128	1.0620848796994158E-4
84-85	7.080565864662773E-5	3.5402829323313864E-5	0.0	9.132177525363472	1.0620848796994158E-4
86-87	7.080565864662773E-5	3.5402829323313864E-5	0.0	9.810920569150046	1.0620848796994158E-4
88-89	7.080565864662773E-5	3.5402829323313864E-5	0.0	10.551795578399034	1.0620848796994158E-4
90-91	7.080565864662773E-5	3.5402829323313864E-5	0.0	11.331171164537128	1.0620848796994158E-4
92-93	7.080565864662773E-5	3.5402829323313864E-5	0.0	12.13479768876169	1.770141466165693E-4
94-95	7.080565864662773E-5	3.5402829323313864E-5	0.0	12.921908793106928	1.770141466165693E-4
96-97	7.080565864662773E-5	3.5402829323313864E-5	0.0	13.734545337394273	1.770141466165693E-4
98-99	7.080565864662773E-5	5.3104243984970795E-5	0.0	14.592957739996665	1.770141466165693E-4
100-101	7.080565864662773E-5	7.080565864662773E-5	0.0	15.52460089505433	1.770141466165693E-4
102-103	7.080565864662773E-5	7.080565864662773E-5	0.0	16.47344982516313	1.770141466165693E-4
104-105	7.080565864662773E-5	7.080565864662773E-5	0.0	17.42022768975651	1.770141466165693E-4
106-107	7.080565864662773E-5	7.080565864662773E-5	0.0	18.358455771068314	1.770141466165693E-4
108-109	7.080565864662773E-5	7.080565864662773E-5	0.0	19.315057920798914	1.770141466165693E-4
110-111	7.080565864662773E-5	7.080565864662773E-5	0.0	20.332375922819	1.770141466165693E-4
112-113	7.080565864662773E-5	7.080565864662773E-5	0.0	21.3737855501936	1.770141466165693E-4
>>END_MODULE
>>Kmer Content	fail
#Sequence	Count	PValue	Obs/Exp Max	Max Obs/Exp Position
GTATCAA	8455	0.0	31.786375	1
CATGGGG	7315	0.0	29.476759	4
GTACATG	12260	0.0	29.163446	1
TACATGG	12390	0.0	28.12454	2
AACGCAG	9555	0.0	27.473637	6
TCAACGC	9490	0.0	27.428413	4
TATCAAC	9895	0.0	26.788296	2
ACATGGG	12515	0.0	26.653732	3
CAACGCA	9790	0.0	26.587912	5
ATCAACG	9815	0.0	26.581818	3
GGTATCA	6295	0.0	24.42317	1
ACGCAGA	10685	0.0	24.176458	7
CGCAGAG	10895	0.0	23.65457	8
GCAGAGT	11930	0.0	20.853672	9
ATGGGGA	4000	0.0	19.805103	5
GAGTACT	3730	0.0	19.54222	12-13
TAGGACG	305	1.6286504E-7	19.529253	4
GTATAGG	615	0.0	19.379072	1
ATGGGGG	3845	0.0	19.054354	5
GTATTAG	910	0.0	18.335583	1
>>END_MODULE